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First published online October 10, 2008

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Shh... autonomous axon guidance in progress

The motility of many cell types is controlled during development by Shh secreted by adjacent tissues (non-autonomous signalling). Now, unexpectedly, Cristina Sánchez-Camacho and Paola Bovolenta uncover a role for autonomous Shh signalling in the growth and guidance of mouse retinal ganglion cell (RGC) axons (see p. 3531). In mammals, the axons of contralateral RGCs (C-RGCs) cross the developing brain's midline (a source of Shh signals), whereas ipsilateral RGC (I-RGC) axons do not. The researchers first show that mouse C-RGCs but not I-RGCs express Shh. Then, by blocking Shh activity in vivo with antibodies, they show that midline-derived Shh funnels C-RGC axons to the contralateral side of the brain. Finally, by blocking Shh signal transduction in the RGCs themselves, they show that the outgrowth of C-RGCs is impaired well before they reach the midline, which indicates that the axons of these neurons require autonomously produced Shh for proper extension. Thus, the researchers conclude, Shh signalling influences growth cone behaviour both autonomously and non-autonomously.

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Related articles in Development:

Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons

Cristina Sánchez-Camacho and Paola Bovolenta
Development 2008 135: 3531-3541. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?