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Figure 5


Fig. 5. Comparative expression of Wnt pathway genes in Gata4/Fog2 and Wnt4 mutants. (A-D) The GATA4-FOG2 complex is essential for canonical β-catenin signaling. Gonads from E12.5 mouse embryos carrying Axin2lacZ and either wild-type (A,B) or homozygous mutant (C,D) Fog2 were stained with X-Gal, which labels Axin2lacZ-positive cells. Only the ovary (B) is positive for Axin2lacZ expression. (E-L) ISH was performed with the indicated probes on XX gonads from wild-type, Gata4ki/ki and Fog2-/- E12.5-13.5 embryos. (M) qRT-PCR analysis of Sp5, Irx3 and Rspo1 gene expression in wild-type and Gata4ki/ki E12.5 XX gonads. (N) qRT-PCR analysis of gene expression in wild-type and Wnt4-/- E12.5 gonads.





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