spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 6


Fig. 6. Ephb4 loss-of-function mutation elicits DA enlargement and CV underdevelopment resembling Efnb2 loss-of-function and Notch gain-of-function mutant morphology. (A,B) Whole-mount CD31 staining of E9.5 (20 ss) embryos. (C,D) Higher magnifications of A, B, respectively. Note the enlarged DA (arrows and white brackets) and underdeveloped ACV (arrowheads and blue brackets) in the Ephb4-deficient embryo (B,D). (E,F) CD31 (red) and ephrin B2-H2BGFP (green) staining of E9.5 (22 ss) embryo cross-sections. The enlarged mutant DA contains ephrin B2- ECs (F, black arrowheads) not seen in the control (E). Nuclei were stained with DAPI (blue). (G,H) CD31 (red) and EphB4-tauLacZ (green) staining of E9.5 (20 ss) embryo cross-sections. Note that the enlarged mutant DA (arrow) contains EphB4-tauLacZ+ ECs (H) not seen in the control (G). Scale bars: 200 µm in B,D; 100 µm in F,H.





Right arrow Return to article