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Fig. 9. Treatment of mice with the Cyp26 inhibitor R115866 causes axial
hyperossification and fusion of cervical vertebrae. (A-D) Alcian
Blue (cartilage) and Alizarin Red (bone matrix) stainings of mouse fetuses at
E18.5. Dorsal views. (A,C) Control mice treated with vehicle (PEG 200). (B,D)
Mice treated with R115866. (A,B) View of cervical vertebrae (c), with fusions
of the neural arches of c3-c5 in an R115866-treated animal. (C,D) View of
thoracic and sacral vertebrae, with precocious fusions of centra (ce) and
neural arches (na), and broader ribs (rb) in the R115866-treated animal.
