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Fig. 2. Dll1 expression and Notch1 activation are segregated into distinct cells
in the VZ of the developing mouse telencephalon. (A-H) Brain
sections from ICR mouse embryos at E13.5 were immunostained with anti-active
Notch1 (actN1) and anti-Dll1 and TO-PRO-3 (nuclear staining). Higher
magnifications of the boxed regions in C and G are shown in D and H,
respectively. Arrowheads in D,H indicate Dll1-positive actN1-negative cells in
the VZ. (I) The proportions of active Notch1-positive cells among
Dll1-negative or Dll1-positive cells in the VZ of the neocortex were
determined by immunohistochemical analysis. Data are the mean ± s.e.m.
of values from three sections of each brain, and similar results were obtained
from six independent brains. *P<0.0005. NCX, neocortex;
GE, ganglionic eminence. Scale bars: 20 µm.
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