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Fig. 6. Fgf8a induces NC at the anterior neural fold indirectly. (A)
The anterior neural plate (blue) is devoid of NC tissue (orange) as a result
of the activity of a Wnt inhibitor, Dkk1
(Carmona-Fontaine et al.,
2007). Snail2 expression is shown in a control embryo at
stage 15. (B) β-catenin misexpression (200 pg) can overcome this
inhibition to induce NC markers (Snail2) at the anterior neural fold (arrows).
(C) Fgf8a (5 pg) misexpression can also induce NC markers
(Snail2 and Sox8) at the anterior neural fold (arrows), an
activity that is mediated by upregulation of Wnt8 in this region of
the embryo (arrows). (D) Normal pattern of expression of Wnt8 in a
control embryo at the same stage. In all panels the embryos are viewed from
the dorsal side, anterior to the top.
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