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Fig. 8. The anteroposterior pattern of the developing palatal shelves is not disrupted in the Mn1^-/- mutant embryos. (A-F) Expression of Fgf10 along the anteroposterior axis of the developing palatal shelves in wild-type (A-C) and Mn1^-/- mutant (D-F) embryos at E13.5. Fgf10 showed similar restricted expression pattern in the anterior and middle palatal regions in both wild-type and Mn1^-/- mutant embryos. (G-L) Expression of Shox2 along the anteroposterior axis of the developing palatal shelves in wild-type (G-I) and Mn1^-/- mutant (J-L) embryos at E13.5. Shox2 mRNA is strongly expressed in the anterior and absent in the posterior palatal regions in wild-type embryos (G-I). In the middle palate, Shox2 mRNA expression is restricted in the proximolateral region (H). The expression pattern and levels of Shox2 mRNA are not altered in Mn1^-/- mutant (J-L) embryos. (M-O) Meox2 mRNA expression is restricted to the middle and posterior regions, and is absent from the anterior region of the developing palate in wild-type embryos at E13.5. (P-R) The levels and anteroposterior pattern of Meox2 mRNA expression pattern in E13.5 Mn1^-/- mutant embryo are comparable with that of the wild-type littermate (M-O). p, palatal shelf; t, tongue. Arrows indicate the mandibular first molar tooth germs and asterisks indicate the maxillary first molar tooth germs in the mid-palatal sections.

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