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First published online November 7, 2008

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How FGF Wnts the neural crest over

The neural crest (NC) is a population of migratory cells that originates at the edge of the neural plate and differentiates into many cell types, including neurons and pigment cells. NC induction in Xenopus depends on signalling through the canonical Wnt and FGF signalling pathways - but do these two pathways interact during NC induction or function independently? On p. 3903, Jean-Pierre Saint-Jeannet and co-workers report that Fgf8a induces the NC indirectly by activating Wnt8. The researchers show that NC induction by Fgf8a requires active canonical Wnt signalling, whereas Wnt8 can induce NC independently of Fgf8a. Moreover, they demonstrate that Fgf8a is a potent inducer of Wnt8 in both explant culture and whole embryos, and is required for the expression of Wnt8 adjacent to the NC-forming region. These findings solve the riddle of the link between Wnt and FGF signalling by showing that they are part of the same NC induction cascade and that their interaction is required for proper NC specification.

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Related articles in Development:

Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm

Chang-Soo Hong, Byung-Yong Park, and Jean-Pierre Saint-Jeannet
Development 2008 135: 3903-3910. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?