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Figure 8


Fig. 8. Model of the role of PTK7 in neural crest migration. (A) Overexpression of PTK7 recruits dsh to the plasma membrane, leading to activation of PCP and enabling neural crest migration. The interaction of PTK7 and dsh may involve fz7 (indicated as?). (B) Deletion of the conserved kinase domain of PTK7 inhibits membrane localization of dsh and inhibits neural crest migration. (C) {Delta}DEP dsh can be recruited to the membrane by PTK7, but lacks PCP activity and therefore blocks neural crest migration.





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