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Fig. 6. A model summarizing Pax6 functions in retinal progenitor cells.
(A) In the central retina, close to the differentiation front (arrows),
Pax6 is required for the normal expression profile of transcription factors
that play a role in the execution of specific retinal lineages but is
dispensable for the completion of neurogenesis. (B) In the peripheral
RPCs, Pax6 inhibits Crx expression and at the same time is essential for
proneural gene expression and completion of the neurogenic program. The
involvement of Pax6 in the regulation of Crx and Otx places Pax6 upstream in
the transcriptional network that regulates PR specification and
differentiation. The requirement for Otx and Crx encompasses the determination
and specification of both rod and cone photoreceptors. Later, the terinoids
and thyroid hormone (e.g. Trβ2) nuclear receptors function within the
cone precursors for the distinction between the M and S cone types
(Hennig et al., 2008). nnp,
non-neuronal progenitors; nbl, neuroblast layer; prp, photoreceptor precursor
layer.
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