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Fig. 2. Zic2 is expressed ectopically in nasal retina of
Foxg1-/- embryos. Zic2 (green) and Brn3a (red)
immunohistochemistry in (A-H) wild-type and (I-P) Foxg1-/-
retinas at E14.5. (E-H) Higher magnifications of boxed areas in A-D,
respectively. (M-P) Higher magnifications of boxed areas in I-L, respectively.
(A,B,E,F) In wild-type dorsal retina, there are
few Zic2-expressing cells in the inner retinal (RGC) layer; some are seen in
other layers and there is strong expression in CMZ (marked in F), as reported
previously (Herrera et al.,
2003). (C,D,G,H), Zic2-expressing
inner retinal layer cells are found predominantly in VT retina clustered
adjacent to the CMZ (in boxed area in C).
(I,J,M,N) In Foxg1-/- dorsal
retina; numerous Zic2-expressing cells are seen nasally, adjacent to the CMZ
in the inner retinal layer (boxed area in J).
(K,L,O,P) In Foxg1-/- ventral
retina; Zic2-expressing inner retinal layer cells are seen both nasally and
temporally (boxed areas in K and L). Abbreviations: N, nasal; T, temporal;
cmz, ciliary marginal zone. Scale bars: 200 µm in A-D,I-L; 100 µm in
E-H,M-P.
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