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Figure 6


Fig. 6. The Lrig3 mutant lateral canal truncation is rescued by removal of one copy of Ntn1. (A-F) Paintfilled E14.5 inner ears from transheterozygous intercross littermates. Canals (arrowheads) are normal in wild-type (A) and transheterozygous (B) embryos, whereas the lateral canal is truncated in Lrig3 homozygotes (C). The truncation is fully rescued when one wild-type copy of Ntn1 is removed from Lrig3 homozygotes (D). Fusion does not occur in Ntn1 mutants (E) or in Ntn1;Lrig3 double mutants (F). (G) Table summarizing the proportion of ears with normal, truncated or unfused semicircular canals for each genotype in offspring from Ntn1+/-; Lrig3+/- intercrosses. The rescued population is highlighted in green. Note that the Ntn1 phenotype is not influenced by the absence of Lrig3.





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