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Figure 5


Fig. 5. Brg1fl/fl:Tie2-Cre+/0 yolk sac vascular remodeling is abnormal. (A,B) Anti-PECAM1-stained yolk sacs from E8.5 littermate Brg1fl/+ (A) and Brg1fl/fl:Tie2-Cre+/0 (B) embryos display a comparable vascular plexus. (C,D) Anti-PECAM1-stained yolk sacs from E9.5 littermate Brg1fl/fl (C) and Brg1fl/fl:Tie2-Cre+/0 (D) embryos. (E) A higher magnification view of a different region of the Brg1fl/fl:Tie2-Cre+/0 yolk sac shown in D. Arrows indicate sprouting or regressing vessels; arrowheads indicate abnormally thin vessels. Scale bars: 500 µm.





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