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Fig. 10. Abnormal calretinin- and GABA-positive neurons in E17.5 mutant brain. Calretinin (A-H) or GABA (I-N) immunohistochemistry in sections from normal (A-D,I-K) and mutant (E-H,L-N) forebrains. (A,E,I,L) General views of normal and mutant forebrain sections (dorsal region). Lower panels show progressively more enlarged details. (B,F,J,M) Details of the cortical region. The boxed regions in B and F are shown in C,D and G,H, respectively. Arrows in B indicate calretinin-positive neurons that reached the more external cortical layers following migration. Neurons in these positions are much rarer in the corresponding mutant section (F). C shows neurons that reached deep layers of the cortical plate; in the corresponding region of the mutant (G), no cells are seen. (D) Subcortical fiber bundles (along which calretinin-positive cells migrate from ganglionic eminences to cortex at earlier stages); no cells are seen here in the wild type. In the corresponding region of the mutant (H), calretinin-positive cells are still seen along this migratory route. (K,N) Enlarged details of J and M. In mutant (N), general disorganization of the GABA-positive neurons and of their arborizations is seen. V, ventricle; VZ, ventricular zone; CP, cortical plate.

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