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Figure 12


Fig. 12. Impaired neuronal maturation in adult olfactory bulb of Sox2 mutant mice. (A) Immunofluorescence of BrdU/NeuN-double positive (red and green, yellow in overlay; first row) and BrdU-single-positive (red only; second row) cells in olfactory bulb sections. Histograms: percentage of BrdU/NeuN double-positive cells within the total BrdU-positive population in normal (WT) and mutant (MUT) olfactory bulb, in the entire bulb (TOT) or specifically in the granule layer (GL) and periglomerular layer (PGL) neuronal populations. Results from wild-type (n=4) and mutant mice (n=6). (B) Calretinin-positive cells (green) in olfactory bulb. Histograms: quantitation of calretinin-positive cells in normal (WT) and mutant (MUT) olfactory bulb within the periglomerular layer (four wild type, six mutants). (C) Confocal microscopy of calretinin-positive cells in the olfactory bulb reveals very limited arborization of mutant (mut) cells compared with wild type (wt). This morphology was clearly detected in two out of the four mutant mice analyzed.





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