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Figure 2


Fig. 2. Spina bifida in PDGFR{alpha} mutant embryos. Skeletal preparations of E18.5 embryos display defects in lumbar vertebrae formation. (A) Control, (B) PDGFR{alpha}CKO (C) PDGFR{alpha}PI3K/PI3K and (D) PDGFR{alpha}TKO. Headings at the top of each column indicate the bone isolated. L, lumbar; T, thoracic. The lumbar vertebral arches form normally in A and B but fail to progress in C and D. Vertebral arch development of the thoracic vertebrae and limbs was normal in all embryos. Arrows indicate the extent that Alcian Blue cartilage can be detected. Scale bars: 1 mm. Asterisks indicate location of bones lost during dissection. sp, spinous process; l, lamina; vb, vertebral body; r, rib. Data representative of skeletal preparations performed on E18.5 and P1 embryos: wild type (n=10); PDGFR{alpha}CKO (n=4); PDGFR{alpha}PI3K/PI3K (n=10); and PDGFR{alpha}TKO (n=9).





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