QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online January 11, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Par-sing the regulatory circuitry of oocyte polarity

In Drosophila oocytes, polarization of the microtubule cytoskeleton localizes the maternal RNAs that subsequently specify the anteroposterior (AP) and dorsoventral axes, but how is cytoskeletal polarity established and regulated? On p. 463, Tian and Deng report that the tumour suppressor Lethal (2) giant larvae (Lgl) and atypical protein kinase C (aPKC) play important roles in regulating microtubule polarity and in setting up the AP axis in Drosophila oocytes. They show that the loss of lgl in germline cells disrupts the normal localization of oocyte polarity markers. Restriction of Lgl activity to the posterior of the oocyte by anterior aPKC (Lgl is inactivated by phosphorylation by aPKC) is also needed for the correct localization of these markers, they report. Furthermore, active Lgl regulates the posterior enrichment of Par-1, a serine/threonine kinase that controls microtubule polarity in Drosophila oocytes. Together, these results indicate that a regulatory circuit that involves Lgl and its phosphorylation by aPKC establishes oocyte polarity.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila

Ai-Guo Tian and Wu-Min Deng
Development 2008 135: 463-471. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?