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Figure 2


Fig. 2. Histology of glomerular development. (A-C) Toluidine blue-stained sections from newborn mouse kidneys. (A) S-shaped body. P, podocyte progenitors; GC, glomerular cleft. A capillary loop is present in the cleft. B, Bowman's capsule. (B) Immature glomerulus showing the `bowl'-shaped arrangement of the podocytes. Cap, capillary loops. (C) Mature glomerulus. P, podocytes; M, mesangial cells. (D) Scanning electron micrograph of the interior of an adult rat glomerulus showing interdigitating foot processes (FP) encompassing capillary loops. P, podocyte cell body. (E) Transmission electron micrograph of a newborn mouse glomerulus. FP, foot processes; GBM, glomerular basement membrane; End, endothelial cell; Cap, capillary lumen. (F) Transmission electron micrograph from an {alpha}3 integrin mutant newborn mouse kidney, showing malformed foot processes and fragmented glomerular basement membrane. Image in D kindly provided by Wilhelm Kriz (Heidelberg).





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