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Fig. 5. Schematic of the slit diaphragm and other important proteins involved in
maintaining foot process assembly. Many proteins are omitted to emphasize
the two major complexes of proteins discussed in the text. For clarity, one
complex is shown within the left foot process, the other in the right foot
process. Two adjacent foot processes are shown. In the left foot process is
the nephrin-FYN-NCK complex, associated with an actin filament. In the right
foot process, the nephrin-podocin-CD2AP complex and the integrin-linked kinase
(ILK)-parvin-pinch complex associated with both 
3β1 integrin and
nephrin are shown. Synaptopodin and -actinin 4 are also shown
associated with the cytoskeleton, the latter also with integrins. Nephrin and
FAT are shown as two major proteins that bridge the space between adjacent
foot processes, although, as noted in the text, nephrin also associates with
Neph proteins. The integrin and dystroglycan complexes are shown in each foot
process. P, phosphorylation (see key for other abbreviations used in the
figure).
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