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Fig. 6. A comparison of normal and 
3 integrin mutant mouse
glomerular development. (A,C,E) Successive stages of normal mouse
glomerular development. (A) Capillary loop stage, at which time the
podocytes (P) still resemble a columnar epithelium and are forming a
`bowl'-shaped sheet into which capillaries are beginning to branch from a
single loop into multiple loops. Scale bar: 8 µm. (B) The capillary
loop stage is relatively normal in the absence of 3β1 integrin.
(C) Intermediate stage of glomerular development, where podocytes have
begun to lose their cell-cell attachments and migrate around capillary loops.
Mesangial cells (darker nuclei) are present in the middle of the glomerulus,
where podocytes are beginning to encompass capillary loops. (D) In the
absence of 3β1 integrin, podocytes have completely lost cell-cell
attachments, and their cell bodies appear to be connected by a thin `neck' to
the basement membrane. (E) Mature normal glomerulus. (F) In the
absence of 3β1 integrin, abnormally wide capillary loops are
present, and podocytes are mainly situated in the peripherly of the
glomerulus. GC, glomerular cleft. [Reproduced from Kreidberg et al.
(Kreidberg et al., 1996).]
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