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Figure 9


Fig. 9. Schematic representation of P-cadherin protein and CDH3 mutations, and diagram of the EC1-EC2 calcium-binding site of P-cadherin. Mutations that were identified in this study are indicated in bold and underlined. Note that the mutation E118G corresponds to E11 in the mature protein. In the diagram, the side chain of E11 is colored in red. EC1-EC5, extracellular cadherin repeat domains; IC, intracellular domain; TM, transmembrane domain.





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