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Figure 4


Fig. 4. Compromised proliferation in Frs2{alpha}cn prostates during prepubertal and pubertal growth stages. (A) Prostate tissues were collected from control and mutant mice at the indicated ages and proliferating cells assessed by immunostaining for PCNA. Note that the proliferating cells mainly reside at the distal tips of the ductal network in 1- or 2-week-old prostates, but are randomly distributed in 4-week-old prostates of both control and mutant mice. Arrows indicate proliferating tips. Representative data from the dorsolateral prostate are shown. Insets are high-magnification views from the same sections. (B) PCNA-stained cells in distal tips of 1- or 2-week-old prostates, or whole prostate (4 weeks old), were scored. The ratio of PCNA-positive to total epithelial cells was calculated from five sections per prostate. Mean±s.d. values of data from three prostates are shown. (C) Real-time RT-PCR analyses of RNAs encoding the indicated genes from 1-week-old prostates. Data were normalized to β-actin loading controls and then presented as the relative difference to the control prostates. Mean±s.d. values of data from three prostates are shown. AP, anterior prostate; DLP, dorsolateral prostate; VP, ventral prostate; F/F, homozygous Frs2{alpha}flox mice; CN, Frs2{alpha}cn mice.





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