QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online January 25, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Dorsal closure in the red

The fusion of epithelial sheets - which is vital in development and wound healing - is commonly studied during dorsal closure (DC), when two epithelial sheets sweep over the fly embryo's surface and fuse at the dorsal midline. During DC, each cell must identify and fuse with its matching cell in the opposing sheet to maintain early AP embryonic patterning. On p. 621, Millard and Martin investigate this process by fluorescently labelling in Drosophila embryos two epithelial populations: P compartment cells with RFP-Moesin and A compartment cells with GFP-Moesin, expressed under the engrailed (en) promoter and a patched (ptc) upstream sequence, respectively. The striped expression patterns of RFP- and GFP-Moesin, the authors report, are maintained throughout DC, leading to perfectly matched red and green stripes, with interactions occurring only between colour-matched filopodia. During both DC and wound repair, filopodia enable cells to find their match and to pull misaligned sheets into alignment. Thus, matching is not limited to leading edge cells, but is likely to involve the adhesion molecules that underpin compartment integrity.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure

Thomas H. Millard and Paul Martin
Development 2008 135: 621-626. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?