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First published online January 25, 2008

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Polo kinase: a polarity player

Polo kinases regulate diverse processes during cell division, including mitotic onset and centrosomal duplication. Rueyling Lin's lab now reports a novel role for the polo kinases PLK-1 and PLK-2 in regulating the polarity of C. elegans embryos (see p. 687). In the one-cell C. elegans embryo, various proteins, including the PAR proteins and the maternal proteins MEX-5 and MEX-6, asymmetrically localize along the AP axis, determining the position of the first mitotic spindle and thus of the first asymmetric division. PLK-1 and PLK-2, Lin's team report, also asymmetrically localize at this stage, in a MEX-5/6-dependent manner, with which they also co-localize. PLK-1/2 interact with MEX-5/6 via the PLK-1/2 polo box domain and also via an amino acid site (T₁₈₆) on MEX-5, which is primed for PLK-dependent phosphorylation by another developmentally regulated kinase, MBK-2. This priming by MBK-2, the authors report, allows the interaction between PLK-1/2 and MEX-5/6, and also the onset of MEX-5/6 function, to be temporally regulated during the crucial oocyte to embryo transition.

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Related articles in Development:

Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6

Yuichi Nishi, Eric Rogers, Scott M. Robertson, and Rueyling Lin
Development 2008 135: 687-697. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?