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First published online January 25, 2008

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Neurogenesis gets the cux

During neurogenesis, progenitor proliferation must be carefully balanced with neuronal differentiation to ensure that the right number of progenitors gives rise to the correct neuronal cell types. This complex process requires that cell-cycle exit is integrated with programs of differentiation and is under intensive investigation. On p. 729, Paul Trainor and colleagues provide new insights into these events with their finding that the transcription factor Cux2 regulates cell-cycle progression and also neuroblast formation and cell-fate determination in the mouse spinal cord. Through gain- and loss-of-function approaches, they show that Cux2 initially influences cell-cycle progression in neural progenitors (its loss causes reduced progenitor numbers). It then regulates cell-cycle exit and neuroblast formation and differentiation by binding directly to the promoters of p27^Kip1 (a G1 cyclin inhibitor) and Neurod (a bHLH protein that promotes neuronal differentiation, partly by activating p27^Kip1). The future identification of other Cux2-interacting partners should reveal further insights into how Cux2 regulates key aspects of spinal cord neurogenesis.

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Related articles in Development:

Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis

Angelo Iulianella, Madhulika Sharma, Michael Durnin, Greg B. Vanden Heuvel, and Paul A. Trainor
Development 2008 135: 729-741. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?