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Fig. 5. Wnt signaling regulates expansion of Isl1+ SHF progenitors
through regulation of Isl1 and FGF signaling. (A) Multiple reports
have demonstrated that Wnt/β-catenin signaling (red) is required upstream
of Isl1 and FGF signaling to promote expansion of SHF stem/progenitor cells
(green) (Ai et al., 2007;
Cohen et al., 2007;
Kwon et al., 2007;
Qyang et al., 2007b).
(B,C) Expression of an activated β-catenin protein in the
secondary heart field (SHF) using the SM22
-cre transgenic line leads to
a dramatic increase in the number of Isl1+ SHF progenitors in the
anterior pharyngeal mesoderm (bracket) and the outflow tract of the mouse
embryonic heart (arrowheads). (B,C) Reproduced, with permission, from Cohen et
al. (Cohen et al., 2007).
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