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Figure 3


Fig. 3. Groucho is phosphorylated by the Torso pathway. Wild-type (A) or mutant (B-F) stage 5 embryos, stained with {alpha}pGro (A,B,C,E) or {alpha}Gro (D,F) antibodies. The genetic inactivation of the Torso pathway, in tsl691 mutant embryos, leads to loss of pGro from the termini (B; compare with A). Reciprocally, pGro staining expands to more central regions in torY9 mutants, in which the Torso receptor is overactive, and a higher than normal uniform staining is observed throughout the embryo (C; compare with A). (D) A torY9 mutant embryo stained with the {alpha}Gro antibody, showing a larger posterior domain devoid of staining (compare with Fig. 2B). The central pGro stripes are not dramatically affected in either tsl691 or torY9 mutants. (E,F) A stage 5 DSor mutant embryo (GLC), stained for {alpha}pGro (E; red) and {alpha}Gro (F; green). pGro staining is absent from the termini (E; compare with A), and is replaced by {alpha}Gro staining, which is not detected normally in this region (compare with Fig. 2B). There are seven pGro stripes in the DSor mutant (E).





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