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Fig. 5. pxt mutants exhibit actin-related defects throughout
oogenesis. (A) Normal ovariole and (B) shortened
pxt ovariole with missing stages, fused chambers (bracket) and
degenerating chambers (star). (C) Multi-nucleate nurse cells in
pxt egg chambers as a result of membrane breakdown. Nurse cell nuclei
are outlined and arrows indicate actin-rich aggregates containing residual
ring canals, compare with S8 in A. (D) Loss of follicular separation
and germarium defects in older pxt mutant females. Broken line indicates
germarium-stage cysts. (E) Defective border cell migration due to
lagging cells (outlined, compare with `BC' in A). (F) Nurse cells
further away from the oocyte have membrane instability (outlined in yellow)
and actin aggregates (arrow), whereas those closer to the oocyte have more
normal actin filament formation (outlined in white). (A-F) Projections of
confocal sections. Green is Hts (1B1) and Fas3 (7G10); red is phalloidin and
blue is DAPI. A, anterior; P, posterior. Scale bars: 50 µM.
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