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Figure 9


Fig. 9. A model for A6.3 endomesoderm specification in Ciona. In A6.3, a combination of Nodal signaling and MAPK signaling maintains an endomesoderm state. Upon cell division, MAPK is inhibited in A7.6 by Ephrin-Ad from neighboring animal blastomeres, allowing endogenous Nodal to activate A7.6 mesoderm genes. In A7.5, Nodal is unable to activate such genes owing to inhibition by MAPK. The fates of blastomeres are indicated in different colors (red, mesoderm; yellow, endoderm).





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