QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online February 8, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Axin' APC levels in Wg signalling

During Drosophila development, the Wingless (Wg) morphogen modulates the activity of the transcriptional activator Armadillo (Arm/β-catenin) by inactivating a destruction complex that targets it for proteolysis. In the prevailing model of Wg signal transduction, Axin levels limit the activity of this destruction complex (consisting of Axin, Apc and the GSK3 homolog Zeste-white 3), whereas Apc is present in vast excess. Now, on p. 963, Benchabane and co-workers propose that Apc activity is also present in limiting amounts in the developing Drosophila retina, to ensure accurate concentration-dependent responses to Wg. When the researchers tested the prevailing model in developing retinas, they unexpectedly discovered that the loss of Apc2 (which reduces total Apc activity by less than twofold) caused ectopic Wg signalling and aberrant cell fate specification in regions of low Wg concentration. The researchers conclude that within the retinal Wg gradient, both Axin and Apc are present near the threshold levels required for Arm destruction, and together ensure accurately graded responses to Wg.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen

Hassina Benchabane, Edward G. Hughes, Carter M. Takacs, Jason R. Baird, and Yashi Ahmed
Development 2008 135: 963-971. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?