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Fig. 3. The prenatal morphogenesis of Catnb^ex3K14/+ mutant hair follicles is disturbed. (A-L) Histological sections of embryonic skin showed that the first morphological signs of hair placodes were evident in the controls at E14 (C). They reached germ stage by E15.5 (G) and stage 4 at E17 (I,K). Placodes of second-wave hair follicles had also appeared at E17 (I). In Catnb^ex3K14/+ mutant skin, epithelial thickenings were already present at E13.5 (B). New placodes and buds of enlarged size and irregular shape were induced continuously during advancing development (D,F,H,J). Mutant placodes were already observed in dorsal midline at E14.5 (bracket, F). In addition, epithelial budding was initiated from the outer root sheath of follicles (arrowheads in J and L). The layer of condensed mesenchyme was thicker in the mutants both under the placode and under interfollicular epithelium (C-E, curly bracket in F). In addition, the epidermis was thicker in the mutants when compared with control skin (curly brackets in F,K,L). Broken lines show the epithelial-mesenchymal border (A-H,L). Asterisks indicate keratin deposits within the mutant epithelium (L). Arrows indicate placodes and buds. Scale bars: 200 µm.

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