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Figure 5


Fig. 5. Laryngeal-tracheal-bronchial and lung malformations in Rspo2/Lrp6 mutant mice. (A-F) Alcian Blue stained cartilages in the larynx, trachea and bronchi from E18.5 fetuses of indicated genotypes. Asterisks in B and C indicate fusion of the arytenoids to the cricoid cartilage. (C) Arrow indicates the cricoid; cartilage is absent on the dorsal aspect of the ring, also observed in B and D. (F) The SftpC-rtTA transgene does not target cells within the larynx epithelium and only tracheal ring defects were observed. (G-N) Immunohistochemical analysis for pro-SftpC, a type II epithelial cell marker (G-J); and Ccsp, a nonciliated bronchiolar cell marker (K-N). (G,K) Rspo2+/+;Lrp6+/+; (H,L) Rspo2Tg/Tg;Lrp6+/+; (I,M) Rspo2Tg/Tg;Lrp6-/-; (J,N) Rspo2+/+;Lrp6-/-. Scale bars: 1 mm in F; 10 µm in J and N.





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