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Figure 4


Fig. 4. Endocytic trafficking in the coelomocytes of the unc-108(sm237) mutant is blocked from late endosome to lysosome. (A-D) TR-BSA was injected into the body cavity and its transport through endocytic compartments is shown over time in wild-type (A,C) and unc-108(sm237) mutant (B,D) animals with endosomal marker RME-8::GFP (A,B) or lysosomal marker LMP-1::GFP (C,D). White arrows point to the compartments that contain TR-BSA. The blue arrow in D indicates the normally sized lysosome that lacks TR-BSA. Scale bars: 2.5 µm.





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