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Fig. 4. A Chc+ transgene suppresses aux eye and wing mutant
phenotypes. (A) auxK47/auxD128
Drosophila wing. (B) auxK47/auxD128
wing with one copy of PChc+. The wing is indistinguishable from that
of wild type. (C) Bar chart showing the degree of suppression of
auxK47/auxD128 eyes by a single copy of
PChc+. For each genotype, 51-124 facets in each of ten eyes were
examined. Error bars represent one standard deviation from the mean calculated
for each eye. The effect of PChc+ is significant (Student's
t-test, P<0.001). (D-F) Tangential sections of
adult eyes are shown as examples of data tabulated in C. PChc+
complements Chc1 completely
(Bazinet et al., 1993). The
mutant phenotype of aux hypomorphs reflects some defects in lateral
inhibition (see Fig. 2E), and
mainly defects in R-cell restriction. The same phenomenon was observed for
lqf hypomorphs (Overstreet et
al., 2004). This observation might reflect a particular
requirement for efficient Delta signaling in R-cell restriction, or
mechanistic differences in signaling at different times during eye
development.
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