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Fig. 7. In the absence of BMPRIB, mouse commissural axons are significantly less
responsive to a rat RP explant. (A,A') E11.5 rat RP explants
deflect Tag1+ commissural axons (green) growing within E10.5
wild-type mouse dorsal spinal cord (d-sc) explants by an average angle of
reorientation of 21.8°±2.0 s.e.m. (n=28).
(B,B') Commissural axons deficient in BMPRIA
(Math1::cre;BmprIaflox/flox) are reoriented by a
rat RP explant, to a similar extent (P>0.4) as
BmprIaflox/flox control littermates, with an average
reorientation angle of 20.4°±2.0 s.e.m. (n=18).
(C,C') By contrast, BmprIb-/- commissural
axons are significantly less reoriented by a rat RP explant than wild-type
littermates (P<1.3x10-7), with an average angle
of reorientation of 9.6°±1.9 s.e.m. (n=19). Note that in
the tracings in A', B' and C', only the axons deriving from the mouse d-sc
explant are illustrated. (D) Schematic to illustrate the orientation of
the E11 rat RP explant and the E10.5 mouse d-sc explant. (E) Histogram
of the average angles of reorientation. Scale bar in C: 75 µm for A-C.
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