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Figure 3


Fig. 3. Role of tissue dimensionality for morphogen gradient precision. (A) In a one-dimensional chain of cells, morphogens cannot get beyond the defective cell (red), resulting in a large impact on the gradient. (B) In two-dimensional tissues, the effect of one defective cell is smaller because it can be bypassed (arrows) if morphogen transport is non-directional. (C) In three-dimensional tissues, the effect is even smaller because there are more paths to bypass the defective cell. (D) Logarithmic plot of theoretical {sum}(x) calculated for different dimensions, but otherwise identical parameters. Only the target cells are subject to cell-to-cell variability (solid lines), or both the source and the receiving cells (dashed lines). {lambda}D/a=7, {sigma}D/D0=0, {sigma}k/k0=1, {sigma}j/j0=0.37 (for details, see Fig. S3 in the supplementary material).





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