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Files in this Data Supplement:
Fig. S1. The prostanoid synthesis and signaling pathway. Shown with the enzymes next to the arrows. Antagonists used are listed beside or under the protein in red, agonist in green.
Fig. S2. Injection of tbxas MO leads to pericardial edema. At 72 hpf, larvae that had been injected with 2 ng of tbxas MO had pericardial edema (B), whereas uninjected controls did not (A).
Movie 1. 76 hpf larvae have a valve leaflet. SPIM movie of a Tg(flk1:EGFP)s843 larva taken at 75 fps and shown at 30 fps.
Movie 2. 85 hpf valve leaflet. SPIM movie of a Tg(flk1:EGFP)s843 larva taken at 70 fps and shown at 30 fps.
Movie 3. 63 hpf valve. SPIM movie of a Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva taken at 141 fps and shown at 30 fps.
Movie 4. 55 hpf valve. SPIM movie of a Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva taken at 114 fps and shown at 30 fps.
Movie 5. 72 hpf valve. SPIM movie of a Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva taken at 155 fps and shown at 30 fps.
Movie 6. 96 hpf valve. SPIM movie of a Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva taken at 147 fps and shown at 30 fps.
Movie 7. 102 hpf valve. SPIM movie of a Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva taken at 137 fps and shown at 30 fps.
Movie 8. Inhibition of ErbB signaling disrupts valve function. SPIM movie of a 72 hpf Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva treated with 4 µM AG1478 from 56-72 hpf taken at 141 fps and shown at 30 fps.
Movie 9. Inhibition of TGFβ signaling disrupts valve function. SPIM movie of a 72 hpf Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva treated with 3 µM SB431542 from 56-72 hpf taken at 122 fps and shown at 30 fps.
Movie 10. Inhibition of Cox2 signaling disrupts valve function. SPIM movie of a 72 hpf Tg(flk1:EGFP)s843; Tg(gata1:dsRed)sd2 larva treated with 25 µM CAY10404 from 56-72 hpf taken at 113 fps and shown at 30 fps.
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