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Fig. 7. A balance of TXA2 and PGF2
signaling regulates myocardial
cell shape. Zebrafish embryos were treated with 10 µM SQ29548 and 5
µM AL8810 (A,B), or 15 µM indomethacin
(C,D), an inhibitor of Cox1 and Cox2, imaged with confocal
(A-D), projections made (B,D) and the area (E) and circularity
(F) measured and the 95% confidence interval calculated. Inhibition of
both PGF2 and TXA2 signaling (A,B) or all Cox signaling (C,D) gave
wild-type shape of the myocardium overlying the AVC (A,C) and wild-type
myocardial area (B,D,E), although myocardial circularity was increased (F).
(G) Table of the effects of inhibiting or activating different
signaling pathways. (H) These findings suggest a model in which
Cox2-derived TXA2 supports myocardial elongation, whereas PGF2 arising
from Cox1 action or from the action of both Cox1 and Cox2 inhibits myocardial
elongation.
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