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First published online February 22, 2008

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Illuminating Shh distribution and localisation

During vertebrate nervous system development, a gradient of sonic hedgehog (Shh) ligand secreted by the notochord specifies ventral cell identities in the adjacent neural tube. To visualize Shh signal distribution during this process, Chamberlain and colleagues have engineered mice in which the Shh locus produces bioactive, fluorescently labelled Shh (see p. 1097). Using these mice, the researchers show that Shh ligand produced by the notochord forms a dynamic gradient that spreads through the neural target field as the ventral pattern emerges, and that Shh associates with the apically localized basal body - an organelle that sits at the base of cilia - of neural progenitors during this process. Other experiments indicate that the profile of the Shh gradient depends on negative feedback from the neural target cells and on Shh lipidation and that Shh might move from the notochord into the neural target field along microtubules. Together, these results provide important new insights into Shh signal distribution and transduction during neural tube patterning.

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Related articles in Development:

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

Chester E. Chamberlain, Juhee Jeong, Chaoshe Guo, Benjamin L. Allen, and Andrew P. McMahon
Development 2008 135: 1097-1106. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?