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First published online February 22, 2008

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Worming into nerve regeneration

Palliative care is often the only option for people with CNS injuries - too little is known about the regeneration of adult axons to cure such damage. However, on p. 1129, Gabel and colleagues describe how C. elegans can provide insights into neural regeneration. Using femtosecond laser ablation to cut the axons of specific neurons in adult worms, the researchers show that, as in mammals, neurons in the head rarely regenerate after injury but those in the body reliably regrow. Next, they show that axonal regeneration in the worm's AVM mechanosensory neuron involves exploratory axonal outgrowth and pruning of unwanted axons. By contrast, the initial development of this neuron involves the stereotyped projection of a pioneer axon. Finally, by examining AVM regeneration in worms that lack various axonal guidance molecules, the researchers show that neural wiring during development and rewiring during regeneration have different molecular requirements. Thus, they suggest, C. elegans could be used in genetic screens for new molecules involved in the regeneration of adult neurons.

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Related articles in Development:

Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans

Christopher V. Gabel, Faustine Antoine, Chiou-Fen Chuang, Aravinthan D. T. Samuel, and Chieh Chang
Development 2008 135: 1129-1136. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?