spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 8


Fig. 8. Model of ATM-Chk2-p53 pathway in zebrafish retinal neurogenesis. In the zebrafish retina, mitotic progenitor cells start to generate neurons at 24 hpf. After 24 hpf, the cell cycle duration of retinal progenitor cells shortens and the cell proliferation rate increases. The increase in cell proliferation rate may increase the number of DNA replication errors during retinal neurogenesis. One possible model is that the ATM-Chk2-p53 pathway repairs the replication errors or induces apoptosis to remove retinal neurons with unrepaired DNA damage. This pathway might prevent the accumulation of abnormally differentiated neurons, which possibly compromise the subsequent formation of neural circuits, and might also remove cancer-predisposing cells.





Right arrow Return to article