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Fig. 1. Two cdc-25.1(gf) mutations affect a putative
β-TrCP-like phosphodegron, while rr36 corresponds to a new
temperature-sensitive lf mutation. Schematic representation of
the CDC-25.1 phosphatase highlighting the corresponding amino acid changes:
the two gain-of-function mutations within the β-TrCP motif (blue) in the
N-terminal regulatory domain and the intragenic rr36 mutation
adjacent (N-terminal) to the catalytic phosphatase domains (black and red)
(see Materials and methods for description). The amino acid changes are in
red. The consensus β-TrCP phosphodegron motif is boxed, with its
phosphorylable serines in green.
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