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Fig. 9. Combinatorial actions of Ascl1, Olig2 and Nkx2-2 in oligodendrocyte
differentiation. (A-C) The percentages of cells with three distinct
phenotypes among total virus-infected cells (mean±s.d. from three or
four independent experiments). Viruses used for infection are shown on the
left. (D) Promotion of oligodendrocyte differentiation by the
combinatorial actions of Ascl1, Olig2 and Nkx2-2. The percentages of
NG2+/GalC- (pale colors on the left),
NG2+/GalC+ (middle) and NG2-/GalC+
(dark colors on the right) in the total oligodendrocyte lineage cells are
compared between cultures infected with various viruses.
*P<0.01 compared with the control virus;
%P<0.01 compared with culture infected with Olig2 and
Nkx2-2 viruses. $P<0.01 compared with culture infected
with Ascl1 virus.
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