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Figure 5


Fig. 5. Lrig3 is involved in NC formation by modulating Wnt and Fgf signaling. (A) Lrig3 slightly enhanced Xnr3 and Siamois induction by Wnt3a. Animal cap assay at stage 10, embryos injected with 300 pg Wnt3a or 300 pg Wnt3a + 1 ng Lrig3. (B) NC markers were moderately induced by the combination of Lrig3 and Wnt3a. Embryos were injected with Lrig3 (1 ng), Wnt3a (300 pg), Wnt3a and Lrig3, Chd (300 pg), Chd and Lrig3, and Chd, Wnt3a and Lrig3, and animal caps were assayed at equivalent stage 16. (C) Lrig3 enhanced the induction of Fgf3, Fgf4 and Fgf8 by Wnt3a. RNAs were injected at the concentrations listed in B, and animal caps were assayed at stages indicated.





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