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Figure 3


Fig. 3. Wnt5a affects the VEGF pathway. (A) VEGF expression in E14 wild-type lungs is detected in the epithelium (arrows in inset) and in the interstitial vessels (arrowheads). (B,C) Although epithelial expression is not appreciably altered by Wnt5a mis/overexpression (B), expression is decreased in the interstitial vessels compared with that seen in wild-type (A) or in Wnt3a-infected (C) lungs. (D-F) Flk1 expression in normal E14 lungs (D) shows weak staining in most of the small vessels, which are nearly all interstitially placed (red arrowheads), and in the epithelium (red arrow). Flk1 expression is increased and the positively staining vessels are malpositioned in the Wnt5a-mis/overexpressing lungs (red arrowheads, E) but not in the Wnt3a-mis/overexpressing lungs (red arrowheads, F). No Flk1 expression is detected in Wnt5a lung epithelium (red arrow, E); Wnt3a lung epithelium shows weak staining (red arrow, F).





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