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Fig. 5. Inhibition of Wnt5a by dnRor2 affects pulmonary
development. (A) Ror2 immunohistochemistry demonstrates expression
at E14 in the epithelium (red arrow) and interstitial vessels (red arrowhead)
of wild-type lungs. (B) At E18, Ror2 is expressed in the interstitial
large muscularized vessel (red arrowhead) and surrounding the luminal
epithelium (red arrow and inset). (C,D) H&E staining of
RCAS-dnRor2-infected lungs (D) shows an increase in size compared
with wild type (C). (E,F) Elderberry bark lectin staining
highlights the decrease in endothelium with dnRor2
mis/overexpression.