Supplemental Figure S1
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Fig. S1. Sequence and location of predicted p53-binding sites in the genomic sequence of murine Dlx5 and Dlx6 promoters. Illustration of the relative positions of p53 (solid purple boxes, denominated A-G) predicted sites in the murine Dlx5 (top diagram) and Dlx6 (bottom diagram) promoters (consensus is RRRCWWGYYY ⊢ RRRCWWGYYY). The position of each predicted site relative to the start codon (+1) is indicated. Stretches of highly conserved (mouse/human alignment) sequences are shown (solid yellow boxes on the top). The X5-R1, X5-R2, X6-R1 and X6-R2 regions (see text) are indicated below each diagram (solid black lines). Sequences are as follows. mDlx5: Site A (−967/−940), GGGGACGTCT AGATTCTT GGACATCTCT; Site B (−858/−839), AAATTAGTTG CAACTTGCTT; Site C (−611/−590), GAGCTAGGCC CT GGGACTGCTT; Site D (−344/−314), AAGCAATGCT TTGTTGTGCTA AAACTAGTTG; and Site E (−89/−10), AGCCATGTCT GCTTAGACC AGAGCAGCTC. mDlx6: Site F (−1190/−1163), AGGCTAGATC CGTAGCACT GAGCTGCTCC; and Site G (−1670/−1640), AGACAAATTT AGGACGA AGGCACTTTT.
