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Figure 7


Fig. 7. A model for the regulation of the APC/CFzr/Cdh1 activity during endocycles in Drosophila. Our data indicate that APC/CFzr/Cdh1 activity is required for endocycle progression. During the endocycle, APC/CFzr/Cdh1 targets Geminin, Cyclin A, Cyclin B and Orc1, and possible additional proteins for proteolysis. We propose that APC/CFzr/Cdh1 activity is downregulated during the endocycle by the oscillating activity of the Cyclin E/Cdk2 complex. Oscillation of APC/CFzr/Cdh1 activity allows for the periodic accumulation of Orc1, a component of the pre-RC. See text for details. During the endocycle, staining for the mitotic cyclins and Geminin appears extremely low and consequently the proteins are not shown in this model. However, it is still possible that these proteins are present at low levels in some endocycling cell types.





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