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Fig. 3. Neural stem cell polarity. (A) Drosophila neuroblast
cell polarity. (Left) Proteins that asymmetrically localize in a dividing NB.
Green, apical proteins; red, basal proteins, including those associated with
GMC contact site. Lines between proteins indicate physical interactions. Baz
binds Par6 and aPKC (not shown). Arrow indicates that Baz is required for
Cdc42 localization. T-bar indicates that aPKC excludes Lgl, Numb and Mira from
the cortex, and Lgl excludes aPKC. (Right) Schematic of a dividing NB, showing
the apical (green) and basal (red) cortical domains; spindle and centrosomes,
brown; DNA, yellow. (B) Mammalian neuroepithelial (NE) cell polarity.
(Left) Proteins that asymmetrically localize in a dividing NE cell. Green,
apical proteins; red, AJ-enriched proteins; blue basolateral proteins. Lines
between protein names indicate physical interactions. Par3 binds Par6 and aPKC
(not shown). T-bar indicates that aPKC excludes Lgl and Numb from the cortex.
(Right) Schematic of a dividing NE (center). Spindle and centrosomes, brown;
DNA, yellow. Baz, Bazooka (fly Par3); Insc, Inscuteable; Pins, Partner of
Insc; aPKC, Atypical protein kinase C; Lgl, Lethal giant larvae; Pon, Partner
of Numb; Mira, Miranda; Pros, Prospero; Brat, Brain tumor; Stau, Staufen;
Ecad, E-cadherin; Apc2, Adenomatosis polyposis coli 2; Prom1, prominin 1;
cat, -catenin; βcat, β-catenin; LGN (Gpsm2), a homolog
of Pins.
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