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Fig. 5. Deletion of Foxd3 in the NC has subtle infrequent effects on
heart development. (A) A section through a lineage-labeled control
mouse embryo at 9.5 dpc shows NC entering the developing heart (arrows). Box
indicates area enlarged in inset. (B) In a control embryo at 10.5 dpc,
NC cells are located in PAs 3 and 4 (arrow) and have migrated into the heart
(between arrowheads). (C) At 9.5 dpc, a section through a
Foxd3 mutant embryo shows NC entering the developing heart (arrows).
Asterisk marks blood inside the heart. (D) In a mutant embryo at 10.5
dpc, very few NC cells are migrating into the heart (arrowhead) and very
little NC is detected in PAs 3 and 4 (arrow). (E-H') Corrosion
casts (E-H) and corresponding traces (E'-H') of 16.5 dpc cardiac
outflow tract and associated vessels. The majority of Foxd3 mutants
(13 of 17) are indistinguishable from controls (E,F). A few mutants had a
duplicated left carotid artery (3 of 17) (G) and one mutant had a PTA (H). Ao,
aorta; bca, brachiocephalic artery; dAo, dorsal aorta; DCA, duplicated carotid
artery; lca, left carotid; lsa, left subclavian artery; PT, pulmonary trunk;
PTA, persistent truncus arteriosus; rca, right carotid artery; rsc, right
subclavian artery; *, ductus arteriosus.
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